Immunization with an Autotransporter Protein of Orientia tsutsugamushi Provides Protective Immunity against Scrub Typhus
被引:41
作者:
Ha, Na-Young
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Ha, Na-Young
[1
,2
]
Sharma, Prashant
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Sharma, Prashant
[1
,2
]
Kim, Gwanghun
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Kim, Gwanghun
[1
,2
]
Kim, Yuri
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Kim, Yuri
[1
,2
]
Min, Chan-Ki
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Min, Chan-Ki
[1
,2
]
Choi, Myung-Sik
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Choi, Myung-Sik
[1
]
Kim, Ik-Sang
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Kim, Ik-Sang
[1
]
Cho, Nam-Hyuk
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea
Seoul Natl Univ, Med Res Ctr, Inst Endem Dis, Seoul, South Korea
Bundang Hosp, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
Cho, Nam-Hyuk
[1
,2
,3
,4
]
机构:
[1] Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea
[3] Seoul Natl Univ, Med Res Ctr, Inst Endem Dis, Seoul, South Korea
Background Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi infection. Recently, the rapid increase of scrub typhus incidence in several countries within the endemic region has become a serious public health issue. Despite the wide range of preventative approaches that have been attempted in the past 70 years, all have failed to develop an effective prophylactic vaccine. Currently, the selection of the proper antigens is one of the critical barriers to generating cross-protective immunity against antigenically-variable strains of O. tsutsugamushi. Methodology/Principal Findings We examined the potential role of ScaA protein, an autotransporter protein of O. tsutsugamushi, in bacterial pathogenesis and evaluated the protective attributes of ScaA immunization in lethal O. tsutsugamushi infection in mice. Our findings demonstrate that ScaA functions as a bacterial adhesion factor, and anti-ScaA antibody significantly neutralizes bacterial infection of host cells. In addition, immunization with ScaA not only provides protective immunity against lethal challenges with the homologous strain, but also confers significant protection against heterologous strains when combined with TSA56, a major outer membrane protein of O. tsutsugamushi. Conclusions/Significance Immunization of ScaA proteins provides protective immunity in mice when challenged with the homologous strain and significantly enhanced protective immunity against infection with heterologous strains. To our knowledge, this is the most promising result of scrub typhus vaccination trials against infection of heterologous strains in mouse models thus far.
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USA
Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USAHoward T Ricketts Lab, Argonne, IL 60439 USA
Cardwell, Marissa M.
Martinez, Juan J.
论文数: 0引用数: 0
h-index: 0
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USA
Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USAHoward T Ricketts Lab, Argonne, IL 60439 USA
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USAUniv Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Chan, Yvonne Gar-Yun
Riley, Sean Phillip
论文数: 0引用数: 0
h-index: 0
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USAUniv Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Riley, Sean Phillip
Chen, Emily
论文数: 0引用数: 0
h-index: 0
机构:Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Chen, Emily
Martinez, Juan Jose
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Howard T Ricketts Lab, Argonne, IL 60439 USAUniv Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USA
Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USAHoward T Ricketts Lab, Argonne, IL 60439 USA
Cardwell, Marissa M.
Martinez, Juan J.
论文数: 0引用数: 0
h-index: 0
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USA
Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USAHoward T Ricketts Lab, Argonne, IL 60439 USA
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USAUniv Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Chan, Yvonne Gar-Yun
Riley, Sean Phillip
论文数: 0引用数: 0
h-index: 0
机构:
Howard T Ricketts Lab, Argonne, IL 60439 USAUniv Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Riley, Sean Phillip
Chen, Emily
论文数: 0引用数: 0
h-index: 0
机构:Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Chen, Emily
Martinez, Juan Jose
论文数: 0引用数: 0
h-index: 0
机构:
Univ Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA
Howard T Ricketts Lab, Argonne, IL 60439 USAUniv Chicago, Dept Microbiol, Cummings Life Sci Ctr 707A, Chicago, IL 60637 USA