Antiviral in vitro activity of Hypericum perforatum L. extract on the human cytomegalovirus (HCMV)

被引：0
作者：
Axarlis, S
Mentis, A
Demetzos, C
Mitaku, S
Skaltsounis, AL
Marselos, M
Malamas, M [1 ]
机构：
[1] Univ Ioannina, Sch Med, Dept Pharmacol, GR-45110 Ioannina, Greece
[2] Hellen Pasteur Inst, Athens 15721, Greece
[3] Univ Athens, Dept Pharm, Div Pharmacognosy, GR-15771 Athens, Greece
来源：
PHYTOTHERAPY RESEARCH | 1998年 / 12卷 / 07期
关键词：
antiviral activity; Hypericum perforatum; St John's wort; HCMV; shell-vial culture;
D O I：
10.1002/(SICI)1099-1573(199811)12:7<507::AID-PTR370>3.0.CO;2-H
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The total methanol extract and chromatographic fractions of the extract of the aerial parts of Hypericum perforatum L. were investigated for their antiviral activity against human cytomegalovirus (HCMV) AD169 laboratory strain by modification of the widely used diagnostic method 'shell-vial' culture. The plant selection was based on its traditional use against viruses of the Herpes family in Greece. The results showed extract fraction III had the most potent antiviral activity against HCMV which was also superior to that of ganciclovir. (C) 1998 John Wiley & Sons, Ltd.
引用
收藏
页码：507 / 511
页数：5
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