Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate

被引：2

作者：

Mohapatra, Sagar Kumar ^{[1
]}

Sahoo, Rudra Narayan ^{[1
,2
]}

Mallick, Subrata ^{[1
]}

Mohapatra, Rajaram ^{[1
]}

机构：

[1] Siksha O Anusandhan Deemed Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Bhubaneswar 751003, Odisha, India

[2] Centurion Univ Technol & Management, Sch Pharm & Life Sci, Bhubaneswar, Odisha, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH | 2021年 / 55卷 / 03期

关键词：

Proton pump inhibitor; Enteric coating; HPMC; Omeprazole; Dissolution enhancement; IN-VITRO; RELEASE; FORMULATION; MECHANISM; HPMCAS;

D O I：

10.5530/ijper.55.3.139

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating. Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV and Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) polymers. The core tablets were subcoated with HPMC E5-LV which acted as a barrier between core tablet and enteric coated tablet. The enteric coating was applied using HPMC-AS. Results: Dissolution information unveiled that the enteric coat remained in place for 2 hr in acidic medium (0.1N HCl) and later dissolved when came in contact with basic media (acetate buffer pH 6.8), it dissolved within a jiffy. Conclusion: The release profile showed 91 to 98% drug release within 1hr in pH 6.8 Acetate buffer. Further instrumental analysis was performed to ascertain drug-polymer interaction.

引用

页码：677 / 684

页数：8