Adherence to the 2018 WCRF/AICR cancer prevention guidelines and chronic lymphocytic leukemia in the MCC-Spain study

被引：0

作者：

Solans, Marta ^{[1
,2
,3
,4
]}

Romaguera, Dora ^{[5
,6
,7
]}

Gracia-Lavedan, Esther ^{[1
,7
,8
]}

Molinuevo, Amaia ^{[9
]}

Benavente, Yolanda ^{[1
,10
]}

Saez, Marc ^{[1
,2
]}

Marcos-Gragera, Rafael ^{[1
,2
,3
,4
]}

Costas, Laura ^{[10
]}

Robles, Claudia ^{[11
]}

Alonso, Esther ^{[12
]}

de la Banda, Esmeralda ^{[12
]}

Gonzalez-Barca, Eva ^{[13
]}

Llorca, Javier ^{[1
,14
]}

Maria Rodriguez-Suarez, Marta ^{[1
,15
]}

Lozano-Lorca, Macarena ^{[16
,17
]}

Aymerich, Marta ^{[18
]}

Campo, Elias ^{[18
,19
]}

Gimeno-Vazquez, Eva ^{[20
]}

Castano-Vinyals, Gemma ^{[1
,7
,8
,21
]}

Aragones, Nuria ^{[1
,22
]}

Pollan, Marina ^{[1
,23
]}

Kogevinas, Manolis ^{[1
,7
,8
,21
]}

de Sanjose, Silvia ^{[1
,10
,24
]}

Amiano, Pilar ^{[1
,9
]}

Casabonne, Delphine ^{[1
,10
]}

机构：

[1] CIBERESP, Madrid 28029, Spain

[2] Univ Girona, Res Grp Stat Econometr & Hlth GRECS, Girona 17003, Spain

[3] Catalan Inst Oncol, Epidemiol Unit, Girona 17004, Spain

[4] Catalan Inst Oncol, Girona Canc Registry, Girona 17004, Spain

[5] Univ Hosp Son Espases, Balearic Isl Hlth Res Inst IdISBa, Palma De Mallorca 07120, Spain

[6] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain

[7] ISGlobal, Barcelona 08003, Spain

[8] UPF, Barcelona 08003, Spain

[9] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian 20014, Spain

[10] Catalan Inst Oncol, IDIBELL, Unit Mol & Genet Epidemiol Infect & Canc UNIC Mol, Canc Epidemiol Res Programme, Av Gran Via lHospitalet 199-203, Lhospitalet De Llobregat 08908, Spain

[11] Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Informat & Intervent Infect & Canc UNIC I&I, IDIBELL, Lhospitalet De Llobregat 08908, Spain

[12] Hosp Univ Bellvitge, Dept Patol, IDIBELL, Lhospitalet De Llobregat 08907, Spain

[13] Catalan Inst Oncol, IDIBELL, Hematol, Lhospitalet De Llobregat 08908, Spain

[14] Univ Cantabria, IDIVAL, Santander 39011, Spain

[15] Univ Oviedo, ISPA FINBA, IUOPA, Oviedo 33003, Spain

[16] Univ Granada, Dept Med Prevent & Salud Publ, E-18071 Granada, Spain

[17] Inst Invest Biosanitaria Granada ibs, Granada 18012, Spain

[18] Univ Barcelona, Hosp Clin, Inst Biomed Res August Pi i Sunyer IDIBAPS, Pathol Dept,Hematopathol Unit, Barcelona 08008, Spain

[19] ISCIII, Ctr Invest Biomed Red Canc CIBERONC, Madrid 28029, Spain

[20] IMIM Hosp del Mar, Hematol Dept, Grup Rec Clin Aplicada Neoplasie Hematol, Canc Res Programme, Barcelona 08003, Spain

[21] Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Spain

[22] Dept Hlth Madrid, Publ Hlth Div, Epidemiol Sect, Madrid 28035, Spain

[23] Carlos III Inst Hlth, Natl Ctr Epidemiol, Canc Epidemiol Unit, Madrid 28029, Spain

[24] Reprod Hlth, PATH, Seattle, WA USA

来源：

CANCER EPIDEMIOLOGY | 2020年 / 64卷

关键词：

Chronic lymphocytic leukemia; WCRF/AICR; 2018; recommendations; Nutrition-based guidelines; Case-control study; NON-HODGKIN-LYMPHOMA; RISK; SUBTYPES; FOOD; MALIGNANCIES; CONSUMPTION; RATIONALE; UPDATE;

D O I：

10.1016/j.canep.2019.101629

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Preventable risk factors for chronic lymphocytic leukemia (CLL) remain largely unknown. The aim of this study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and CLL, in the MCC-Spain case-control study. Methods: A total of 318 CLL cases and 1293 population-based controls were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on the 2018 recommendations for cancer prevention (on body fatness, physical activity, and diet) was constructed. We used logistic regression analysis adjusting for potential confounders. Results: Individuals in the highest tertile of the WCRF/AICR score had an odds ratio for CLL of 1.25 (95 % CI 0.91; 1.73) compared with individuals with low adherence (p-trend = 0.172). Each point increment in the score was associated with an OR for CLL of 1.06 (95 % CI 0.91; 1.23). Analyses by severity of disease did not show significant heterogeneity of effects. Conclusion: Overall, our results do not support an association between the WCRF/AICR score and CLL, yet we might have been limited by statistical power and study design to detect modest associations. Further research, ideally with a prospective design, long follow-up, and including additional lymphoma subtypes, is warranted to confirm the impact of composite healthy lifestyle behaviors on lymphoma risk.

引用

页数：7

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