Acute Hepatitis due to Hepatitis E Virus Genotype 1 As an Imported Infectious Disease in Japan

被引：4
作者：
Miyahara, Koji [1 ]
Miyake, Yasuhiro [1 ,2 ]
Yasunaka, Tetsuya [1 ]
Ikeda, Fusao [1 ,2 ]
Takaki, Akinobu [1 ]
Iwasaki, Yoshiaki [1 ]
Kobashi, Haruhiko [1 ]
Kang, Jong-Hon [3 ]
Takahashi, Kazuaki [4 ]
Arai, Masahiro [5 ]
Yamamoto, Kazuhide [1 ,2 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol, Okayama, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Hepatol, Okayama, Japan
[3] Teine Keijinkai Hosp, Ctr Gastroenterol, Sapporo, Hokkaido, Japan
[4] Toshiba Gen Hosp, Dept Med Sci, Tokyo, Japan
[5] Toshiba Gen Hosp, Dept Gastroenterol, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2010年 / 49卷 / 23期
关键词：
hepatitis E virus; genotype; acute hepatitis; AUTOIMMUNE HEPATITIS; CLINICAL-FEATURES; NEPAL; KATHMANDU;
D O I：
10.2169/internalmedicine.49.4221
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
An 18-year-old Nepalese man was admitted due to general malaise and anorexia a month after coming to Japan. Laboratory tests showed elevation of transaminase and positivity for IgM anti-HEV antibody. Serum HEV RNA was detected by RT-PCR amplifications. An HEV genome phylogenetic tree, constructed using an 821-nucleotide sequence in the open reading frame 1, indicated that the genotype was 1. HEV genotype 1 is epidemic in South Asia, Africa and South America, and the incidence of acute hepatitis due to HEV genotype 1 is low in Japan. Thereafter, attention should be paid to HEV genotype 1 infection as an imported infectious disease.
引用
收藏
页码：2613 / 2616
页数：4
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