Nonsteroidal Antiinflammatory Drug-Related Injury to the Gastrointestinal Tract: Clinical Picture, Pathogenesis, and Prevention

被引：179

作者：

Scarpignato, Carmelo ^{[1
,2
]}

Hunt, Richard H. ^{[3
,4
]}

机构：

[1] Univ Parma, Dept Clin Sci, Div Gastroenterol, I-43100 Parma, Italy

[2] Univ Parma, Sch Med & Dent, Lab Clin Pharmacol, I-43100 Parma, Italy

[3] McMaster Univ, Dept Med, Div Gastroenterol, Hamilton, ON, Canada

[4] Farncombe Family Digest Hlth Res Inst, Hamilton, ON, Canada

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2010年 / 39卷 / 03期

关键词：

Nonsteroidal antiinflammatory drug; Gastrointestinal tract; Pathogenesis; Injury; Prevention; HELICOBACTER-PYLORI INFECTION; LOW-DOSE ASPIRIN; SELECTIVE CYCLOOXYGENASE-2 INHIBITORS; PEPTIC-ULCER DISEASE; SMALL-BOWEL INJURY; DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; COX-2; INHIBITOR; MYOCARDIAL-INFARCTION; CAPSULE ENDOSCOPY;

D O I：

10.1016/j.gtc.2010.08.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Increasing life expectancy in developed countries has led to a growing prevalence of arthritic disorders, which has been accompanied by increasing prescriptions for nonsteroidal antiinflammatory drugs (NSAIDs) These are the most widely used agents for musculoskeletal and arthritic conditions Although NSAIDs are effective, their use is associated with a broad spectrum of adverse reactions in the liver kidney cardiovascular system skin and gut Gastrointestinal (GI) side effects are the most common The dilemma for the physician prescribing NSAIDs is therefore to maintain the antiinflammatory and analgesic benefits while reducing or preventing GI side effects The challenge is to develop safer NSAIDs by shifting from a focus on GI toxicity to the increasingly more appreciated cardiovascular toxicity

引用

页码：433 / +

页数：33

共 170 条

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