Weakly Coordinating, Hydroxyl Directed Ruthenium Catalyzed C-H Alkylation of Ubiquitous Benzyl Alcohols with Maleimides

被引：15
|
作者：
Dethe, Dattatraya H. [1 ]
Beeralingappa, Nagabhushana C. [1 ]
Kumar, Vimlesh [1 ]
机构：
[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 16期
关键词：
FUNCTIONALIZATION; BOND; ACTIVATION; 1,4-ADDITION; ALKENES; ALKYNES;
D O I：
10.1021/acs.orglett.1c02040
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzyl alcohols have been employed as effective coupling partners in Ru-catalyzed C-H functionalization reactions, and their annulation with maleimides then offers efficient synthesis of useful ortho substituted succinimide aromatic aldehydes and ketones. Detailed mechanistic studies have been demonstrated by performing preliminary reactions, deuterium studies, and competitive experiments.
引用
收藏
页码：6267 / 6271
页数：5
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