Serotonin Reuptake Inhibitors and Risk of Abnormal Bleeding

被引：41

作者：

Andrade, Chittaranjan ^{[1
]}

Sharma, Eesha ^{[2
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India

[2] King Georges Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2016年 / 39卷 / 03期

关键词：

Antidepressant; Serotonin reuptake inhibitor; Selective serotonin reuptake inhibitor; Bleeding; Postpartum hemorrhage; Intracranial hemorrhage; Nonsteroidal anti-inflammatory drugs; Antiplatelet drugs; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; POPULATION-BASED COHORT; POSTPARTUM HEMORRHAGE; PREADOLESCENT GIRL; ANTIDEPRESSANTS; METAANALYSIS; STROKE; SERTRALINE; THERAPY; SURGERY;

D O I：

10.1016/j.psc.2016.04.010

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Serotonin reuptake inhibitors (SRIs) increase the risk of abnormal bleeding by lowering platelet serotonin and hence the efficiency of platelet-driven hemostasis; by increasing gastric acidity and possibly gastric ulceration; and by other mechanisms. The upper gastrointestinal tract is the commonest site of SRI-related abnormal bleeding; bleeding at this location may be increased by concurrent nonsteroidal anti-inflammatory drug therapy and by treatment with antiplatelet or anticoagulant drugs. Bleeding at this location may be reduced by concurrent administration of acid-suppressing drugs.

引用

页码：413 / +

页数：15

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