Migraine Headache: Updates and Future Developments

被引：15

作者：

Bohm, Parker E. ^{[1
]}

Stancampiano, Fernando F. ^{[2
]}

Rozen, Todd D. ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA

[2] Mayo Clin, Dept Med, Jacksonville, FL 32224 USA

来源：

MAYO CLINIC PROCEEDINGS | 2018年 / 93卷 / 11期

关键词：

DOUBLE-BLIND; PREVENTIVE TREATMENT; EPISODIC MIGRAINE; PLACEBO; ONABOTULINUMTOXINA; METAANALYSIS; GUIDELINES; EFFICACY; ERENUMAB;

D O I：

10.1016/j.mayocp.2018.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Migraine is a common disabling condition that is frequently managed by primary care providers. In recent years, the growing array of migraine therapies has added complexity to patient care. This article serves as a succinct review of pertinent updates and future directions regarding migraine. Our understanding of pathophysiology has progressed along with new advances in biomarkers and genetics. These discoveries have led to a wealth of new options for treatment, many of which are specifically targeted against molecules implicated in migraine headache such as calcitonin gene-(r)elated peptide. These treatments include several monoclonal antibodies, calcitonin-gene related peptide receptor antagonists, and 5-hydroxytryptamine 1F (5-HT1F) receptor agonists; new options such as these are important for the large population falling out of eligibility for triptans. Furthermore, various nonpharmacological options including noninvasive brain stimulation have joined the arsenal of therapies used for treating migraine. (C) 2018 Mayo Foundation for Medical Education and Research

引用

页码：1648 / 1653

页数：6

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