Synthesis, spectral and structural study of N-[1-(N,N,N′,N′-tetramethylphosphoramidoyl)1H-benzimidazol-2-yl]-propionimidic ethyl ether

The preparation of N-[1-(N, N, N', N'-tetramethylphosphoramidoyl)-1H-benzimidazol-2-yl]-proponimidic ethyl ester 2 has been achieved by the reaction of N-(1H-benzimidazol-2-yl)-proponimidic acid ethyl ester 1 with N, N, N', N'-tetramethylchlorophosphoramide. The structure of compound 2 has been determined by X-ray diffraction. The results of (H-1, C-13, P-31) NMR, IR, EI-MS spectral data are consistent with those obtained from the X-ray diffraction. The compound crystallizes in the triclinic system, following the EsZ conformation. In the crystal, there are two weak C3-H3 center dot center dot center dot 1 and C15-H15 center dot center dot center dot O1 intermolecular hydrogen bonds.