The scope for pneumococcal vaccines that do not prevent transmission

被引：4

作者：

Flasche, Stefan ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, Keppel St, London WC1E 7HT, England

来源：

VACCINE | 2017年 / 35卷 / 45期

关键词：

S; pneumoniae; Vaccine; Replacement; Herd protection; STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; DISEASE;

D O I：

10.1016/j.vaccine.2017.09.073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pneumococcal vaccine pipeline holds candidates developed with the aim to prevent the majority if not all pneumococcal disease. Herd protection is a critical component of the overall impact of current pneumococcal conjugate vaccines (PCVs) and is a prerequisite for disease elimination through an infant vaccination programme. We assessed the scope of a hypothetical pneumococcal vaccine candidate (HPVC) with high clinical efficacy against all pneumococci but that fails to induce such indirect protection. We found that, despite a lack of impact on unvaccinated individuals, HPVC use in infancy may offer similar or superior impact among young children if compared to current PCVs. Hence, it could provide a more affordable alternative to PCVs in particular in settings where most pneumococcal disease is concentrated in children. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：6043 / 6046

页数：4

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