IgG4-related tubulointerstitial nephritis

被引：24

作者：

Cornell, Lynn D. ^{[1
]}

机构：

[1] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55902 USA

来源：

KIDNEY INTERNATIONAL | 2010年 / 78卷 / 10期

关键词：

AUTOIMMUNE PANCREATITIS; DISEASE;

D O I：

10.1038/ki.2010.342

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/autoimmune pancreatitis. On biopsy, this TIN shows an IgG4(+) plasma cell-rich infiltrate, akin to the pancreatic tissue findings in autoimmune pancreatitis, and may show tubulointerstitial immune complex deposits. Notably, some cases may be mass-forming. Recognition of this specific type of TIN can guide appropriate patient therapy.

引用

页码：951 / 953

页数：4

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