Aggregation-induced emission: An emerging concept in brain science

被引：21

作者：

Wu, Qian ^{[1
,3
]}

Li, Youmei ^{[2
]}

Wang, Lei ^{[2
]}

Wang, Dong ^{[1
,2
]}

Tang, Ben Zhong ^{[1
,3
,4
]}

机构：

[1] Shenzhen Univ, Guangdong Res Ctr Interfacial Engn Funct Mat, Shenzhen Key Lab Polymer Sci & Technol, Coll Mat Sci & Engn,Ctr AIE Res, Shenzhen 518061, Peoples R China

[2] Shenzhen Univ, Coll Optoelect Engn, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst, Shenzhen 518060, Peoples R China

[3] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Hong Kong Branch, Dept Chem,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China

[4] Chinese Univ Hong Kong, Sch Sci & Engn, Shenzhen Inst Aggregate Sci & Technol, Shenzhen 518172, Guangdong, Peoples R China

来源：

BIOMATERIALS | 2022年 / 286卷

基金：

中国国家自然科学基金;

关键词：

Aggregation-induced emission; Molecular design; Cerebrovascular imaging; Blood-brain barrier penetration; Brain science; FLUORESCENCE; LUMINOGENS; DESIGN; NANOPARTICLES; MICROSCOPY; DISEASE; AGENTS; DOTS;

D O I：

10.1016/j.biomaterials.2022.121581

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As an emerging concept in brain science, aggregation-induced emission (AIE) has captivated much interest by virtue of the unique superiority of AIE fluorophores in terms of emission intensity, imaging resolution, biocompatibility and photosensitivity. This review mainly overviews the current state-of-art advances of AIE fluomphores achieving the superb performance in brain imaging and therapy, which facilitate deep tissue penetration, high contrast to autofluorescence and efficient blood-brain barrier (BBB) crossing by rational molecular design and functionalized strategies. We expect this review serve as a modest spur to push forward the blooming growth of research in this fertile field.

引用

页数：17

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