The Hippo pathway: an emerging role in urologic cancers

被引：3

作者：

Cinar, Bekir ^{[1
]}

Alp, Esma ^{[1
]}

Al-Mathkour, Marwah ^{[1
]}

Boston, Ava ^{[1
]}

Dwead, Abdulrahman ^{[1
]}

Khazaw, Kezhan ^{[1
]}

Gregory, Alexis ^{[1
]}

机构：

[1] Clark Atlanta Univ, Ctr Canc Res & Therapeut Dev, Dept Biol Sci, Atlanta, GA 30314 USA

来源：

AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL UROLOGY | 2021年 / 9卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Hippo pathway; MST1/STK4; MST1/STK3; LATS1; LATS2; YAP1; signal transduction; cancer biology; urologic cancer; ALLELE-SPECIFIC IMBALANCE; RENAL-CELL CARCINOMA; METASTATIC UROTHELIAL CARCINOMA; CISPLATIN-INELIGIBLE PATIENTS; RESISTANT PROSTATE-CANCER; SIGNALING PATHWAY; ANDROGEN RECEPTOR; TUMOR-SUPPRESSOR; ANTITUMOR-ACTIVITY; PROTEIN-KINASE;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The Hippo pathway controls several biological processes, including cell growth, differentiation, motility, sternness, cell contact, immune cell maturation, organ size, and tumorigenesis. The Hippo pathway core kinases MST1/2 and LATS1/2 in mammals phosphorylate and inactivate YAP1 signaling. Increasing evidence indicates that loss of MST1/2 and LATS1/2 function is linked to the biology of many cancer types with poorer outcomes, likely due to the activation of oncogenic YAP1/TEAD signaling. Therefore, there is a renewed interest in blocking the YAP1/TEAD functions to prevent cancer growth. This review introduces the Hippo pathway components and examines their role and therapeutic potentials in prostate, kidney, and bladder cancer.

引用

页码：301 / 317

页数：17

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