The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

被引：35
作者：
Tian, Wen [1 ,2 ]
Jiang, Shirley Y. [2 ]
Jiang, Xinguo [1 ,2 ]
Tamosiuniene, Rasa [1 ]
Kim, Dongeon [2 ]
Guan, Torrey [1 ]
Arsalane, Siham [1 ,2 ]
Pasupneti, Shravani [2 ]
Voelkel, Norbert F. [3 ]
Tang, Qizhi [4 ]
Nicolls, Mark R. [1 ,2 ]
机构：
[1] VA Palo Alto Hlth Care Syst, Dept Med, Palo Alto, CA 94304 USA
[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
[3] Univ Amsterdam, Med Ctr, Dept Pulm Med, Amsterdam, Netherlands
[4] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
美国国家卫生研究院;
关键词：
regulatory T cell; pulmonary arterial hypertension; sexual dimorphism; right ventricle; estrogen; SEX-DIFFERENCES; FOXP3; EXPRESSION; ESTROGEN; IMMUNE; TREG; HUMAN-HERPESVIRUS-8; PATHOBIOLOGY; AUTOIMMUNITY; PATHOGENESIS; KYNURENINE;
D O I：
10.3389/fimmu.2021.684657
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4(+)CD25(high)FOXP3(+) Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.
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页数：9
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