ADXS-HPV: A therapeutic Listeria vaccination targeting cervical cancers expressing the HPV E7 antigen

被引：48

作者：

Cory, Lori ^{[1
]}

Chu, Christina ^{[2
]}

机构：

[1] Hosp Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[2] Fox Chase Canc Ctr, Dept Surg Oncol, Philadelphia, PA 19111 USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2014年 / 10卷 / 11期

关键词：

ADXS11-001; cervical cancer; human papillomavirus; immunotherapy; Listeria monocytogenes; HPV; FDA; Food and Drug Administration; VLP; virus like protein; Lm; LLO; listeriolysin O; PLC; phospholipase C; MHC; major histocompatibility complex; GOG; Gynecologic Oncology Group; OPSCC; oropharyngeal cancer; PAPILLOMAVIRUS TYPE-16 E7; T-CELL RESPONSES; INTRAEPITHELIAL NEOPLASIA; IMMUNE-RESPONSES; TUMOR-GROWTH; MONOCYTOGENES; REGRESSION; VACCINES; PROTEIN; WOMEN;

D O I：

10.4161/hv.34378

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Listeria monocytogenes is a bacterium that can be genetically modified to express fusion proteins with antigens specific to certain cancer models. This technology has been harnessed to develop ADXS11-001, a vaccine that aims to elicit an immune response against human papillomavirus (HPV) oncoprotein E7.Pre-clinical studies assessing the efficacy of recombinant Listeria vaccination targeting this same oncoprotein have consistently demonstrated successful reduction of in vivo tumor burden among animal cancer models. Several clinical trials are underway to assess the efficacy of ADXS11-001 in eliciting both immune and clinical responses against HPV-related human cervical, oropharyngeal and anal cancers.

引用

页码：3190 / 3195

页数：6

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