Determination of ciprofloxacin in plasma and urine by HPLC with ultraviolet detection

被引：0
|
作者：
Kamberi, M [1 ]
Tsutsumi, K [1 ]
Kotegawa, T [1 ]
Nakamura, K [1 ]
Nakano, S [1 ]
机构：
[1] Oita Med Univ, Dept Clin Pharmacol & Therapeut, Oita 87955, Japan
来源：
CLINICAL CHEMISTRY | 1998年 / 44卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
A simple, sensitive isocratic method for the detection and quantification of ciprofloxacin in plasma and urine has been developed. The assay consisted of reversed-phase HPLC with ultraviolet detection. Plasma proteins were removed by a fast and efficient procedure. For the urine samples, the only required sample preparation was dilution. Separation was achieved on a C-18 reversed-phase column. The quantification limit was 0.01 mg/L in plasma and 0.5 mg/L in urine. This method was sufficiently sensitive for pharmacokinetic studies.
引用
收藏
页码：1251 / 1255
页数：5
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