The role of viruses in acute exacerbations of asthma

被引：287
作者：
Jackson, David J. [1 ]
Johnston, Sebastian L. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Resp Med, Natl Heart & Lung Inst, London W2 1PG, England
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2010年 / 125卷 / 06期
基金：
英国医学研究理事会;
关键词：
Asthma; acute exacerbation; virus; RESPIRATORY SYNCYTIAL VIRUS; NF-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; BRONCHIAL EPITHELIAL-CELLS; RHINOVIRUS; 16; INFECTION; ENDOTHELIAL GROWTH-FACTOR; MESSENGER-RNA EXPRESSION; TOLL-LIKE RECEPTOR-3; ANTIVIRAL ACTIVITY; IN-VITRO;
D O I：
10.1016/j.jaci.2010.04.021
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Viral respiratory infections are the most common cause of an acute asthma exacerbation in both children and adults and represent a significant global health burden. An increasing body of evidence supports the hypothesis that these infections cause a greater degree of morbidity in asthmatic subjects than in the healthy population, emphasizing a discrepancy in the antiviral response of asthmatics. In this review we discuss why such a discrepancy might exist, examining the role of the bronchial epithelium as well as the main inflammatory cells, mediators, and molecular pathways that are involved in the immune response. In addition, the potential impact of virus-induced asthma exacerbations on airway remodelling is reviewed and we explore which therapeutic options might be of benefit in preventing the deterioration of asthma control seen following viral infection. (J Allergy Clin Immunol 2010;125:1178-87.)
引用
收藏
页码：1178 / 1187
页数：10
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