Nanotemplating of Biodegradable Polymer Membranes for Constant-Rate Drug Delivery

被引：38

作者：

Bernards, Daniel A. ^{[1
,2
]}

Desai, Tejal A. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 21期

基金：

美国国家卫生研究院;

关键词：

BLOCK-COPOLYMER; POLYELECTROLYTE MULTILAYERS; NANOTUBE ARRAYS; TIO2; NANOTUBES; DIFFUSION; ALUMINA; IMMUNOISOLATION; SEPARATION; COATINGS; BEHAVIOR;

D O I：

10.1002/adma.200903439

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nanoporous biodegradable polymer (polycaprolactone) is fabricated utilizing a zinc oxide nanotemplate (see figure). Chemical characterization verifies removal of the template, and preliminary tests on the cytotoxicity demonstrate basic bio-compatibility. Diffusion of a model small molecule and a protein are shown to be first and zero order, respectively, indicating these nanoporous membranes may be useful for controlled release of protein-based therapeutics.

引用

页码：2358 / 2362

页数：5

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