A new vision of immunity: homeostasis of the superorganism

被引：160
作者：
Eberl, G. [1 ,2 ]
机构：
[1] Inst Pasteur, Dept Immunol, Lymphoid Tissue Dev Unit, F-75724 Paris, France
[2] CNRS, URA1961, Paris, France
来源：
MUCOSAL IMMUNOLOGY | 2010年 / 3卷 / 05期
关键词：
INFLAMMATORY BOWEL DISEASES; CHRONIC VIRAL-INFECTION; DISTAL GUT MICROBIOME; T-CELL MEMORY; ROR-GAMMA-T; NF-KAPPA-B; COMMENSAL BACTERIA; ADAPTIVE IMMUNITY; INNATE IMMUNITY; PROINFLAMMATORY IL-17(+);
D O I：
10.1038/mi.2010.20
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune system is commonly perceived as an army of organs, tissues, cells, and molecules that protect from disease by eliminating pathogens. However, as in human society, a clear definition of good and evil might be sometimes difficult to achieve. Not only do we live in contact with a multitude of microbes, but we also live with billions of symbionts that span all the shades from mutualists to potential killers. Together, we compose a superorganism that is capable of optimal living. In that context, the immune system is not a killer, but rather a force that shapes homeostasis within the superorganism.
引用
收藏
页码：450 / 460
页数：11
相关论文
共 99 条
  • [11] Brown GD, 2006, NAT REV IMMUNOL, V6, P33, DOI 10.1038/nri1745
  • [12] Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila
    Buchon, Nicolas
    Broderick, Nichole A.
    Chakrabarti, Sveta
    Lemaitre, Bruno
    [J]. GENES & DEVELOPMENT, 2009, 23 (19) : 2333 - 2344
  • [13] Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
    Calcinaro, F
    Dionisi, S
    Marinaro, M
    Candeloro, P
    Bonato, V
    Marzotti, S
    Corneli, RB
    Ferretti, E
    Gulino, A
    Grasso, F
    De Simone, C
    Di Mario, U
    Falorni, A
    Boirivant, M
    Dotta, F
    [J]. DIABETOLOGIA, 2005, 48 (08) : 1565 - 1575
  • [14] Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    Cash, Heather L.
    Whitham, Cecilia V.
    Behrendt, Cassie L.
    Hooper, Lora V.
    [J]. SCIENCE, 2006, 313 (5790) : 1126 - 1130
  • [15] CATO MP, 1934, CATO VARRO AGR
  • [16] Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
    Clarke, Thomas B.
    Davis, Kimberly M.
    Lysenko, Elena S.
    Zhou, Alice Y.
    Yu, Yimin
    Weiser, Jeffrey N.
    [J]. NATURE MEDICINE, 2010, 16 (02) : 228 - U137
  • [17] Hidden killers: persistence of opportunistic fungal pathogens in the human host
    d'Enfert, Christophe
    [J]. CURRENT OPINION IN MICROBIOLOGY, 2009, 12 (04) : 358 - 364
  • [18] Porphyromonas gingivalis lipopolysaccharide contains multiple lipid a species that functionally interact with both toll-like receptors 2 and 4
    Darveau, RP
    Pham, TTT
    Lemley, K
    Reife, RA
    Bainbridge, BW
    Coats, SR
    Howald, WN
    Way, SS
    Hajjar, AM
    [J]. INFECTION AND IMMUNITY, 2004, 72 (09) : 5041 - 5051
  • [19] An ecological and evolutionary perspective on human-microbe mutualism and disease
    Dethlefsen, Les
    McFall-Ngai, Margaret
    Relman, David A.
    [J]. NATURE, 2007, 449 (7164) : 811 - 818
  • [20] Immune Responses to the Microbiota at the Intestinal Mucosal Surface
    Duerkop, Breck A.
    Vaishnava, Shipra
    Hooper, Lora V.
    [J]. IMMUNITY, 2009, 31 (03) : 368 - 376
12345678910