A new vision of immunity: homeostasis of the superorganism

被引：159
作者：
Eberl, G. [1 ,2 ]
机构：
[1] Inst Pasteur, Dept Immunol, Lymphoid Tissue Dev Unit, F-75724 Paris, France
[2] CNRS, URA1961, Paris, France
来源：
MUCOSAL IMMUNOLOGY | 2010年 / 3卷 / 05期
关键词：
INFLAMMATORY BOWEL DISEASES; CHRONIC VIRAL-INFECTION; DISTAL GUT MICROBIOME; T-CELL MEMORY; ROR-GAMMA-T; NF-KAPPA-B; COMMENSAL BACTERIA; ADAPTIVE IMMUNITY; INNATE IMMUNITY; PROINFLAMMATORY IL-17(+);
D O I：
10.1038/mi.2010.20
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune system is commonly perceived as an army of organs, tissues, cells, and molecules that protect from disease by eliminating pathogens. However, as in human society, a clear definition of good and evil might be sometimes difficult to achieve. Not only do we live in contact with a multitude of microbes, but we also live with billions of symbionts that span all the shades from mutualists to potential killers. Together, we compose a superorganism that is capable of optimal living. In that context, the immune system is not a killer, but rather a force that shapes homeostasis within the superorganism.
引用
收藏
页码：450 / 460
页数：11
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