A new vision of immunity: homeostasis of the superorganism

被引：162

作者：

Eberl, G. ^{[1
,2
]}

机构：

[1] Inst Pasteur, Dept Immunol, Lymphoid Tissue Dev Unit, F-75724 Paris, France

[2] CNRS, URA1961, Paris, France

来源：

MUCOSAL IMMUNOLOGY | 2010年 / 3卷 / 05期

关键词：

INFLAMMATORY BOWEL DISEASES; CHRONIC VIRAL-INFECTION; DISTAL GUT MICROBIOME; T-CELL MEMORY; ROR-GAMMA-T; NF-KAPPA-B; COMMENSAL BACTERIA; ADAPTIVE IMMUNITY; INNATE IMMUNITY; PROINFLAMMATORY IL-17(+);

D O I：

10.1038/mi.2010.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system is commonly perceived as an army of organs, tissues, cells, and molecules that protect from disease by eliminating pathogens. However, as in human society, a clear definition of good and evil might be sometimes difficult to achieve. Not only do we live in contact with a multitude of microbes, but we also live with billions of symbionts that span all the shades from mutualists to potential killers. Together, we compose a superorganism that is capable of optimal living. In that context, the immune system is not a killer, but rather a force that shapes homeostasis within the superorganism.

引用

页码：450 / 460

页数：11

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