Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome: A Review

被引：18
|
作者：
Parmar, Simrit [1 ]
de Lima, Marcos [1 ]
Deeg, H. Joachim [2 ,3 ]
Champlin, Richard [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cell Therapy, Houston, TX 77005 USA
[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
[3] Univ Washington, Sch Med, Seattle, WA USA
来源：
SEMINARS IN ONCOLOGY | 2011年 / 38卷 / 05期
关键词：
ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; INTENSITY CONDITIONING REGIMEN; IDENTICAL SIBLING DONORS; TOTAL-BODY IRRADIATION; LOW-DOSE AZACITIDINE; VERSUS-HOST-DISEASE; REDUCED-INTENSITY;
D O I：
10.1053/j.seminoncol.2011.04.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Allogeneic hematopoietic stem cell transplantation (HSCT) continues to be the only curative option for myelodysplastic syndrome (MDS). Since the majority of the patients with this disease are often older and frail, treatment-related mortality and morbidity remain major obstacles to be overcome. Reduced-intensity conditioning and continued lines of investigation in the field of allogeneic transplantation are expected to ultimately improve the overall therapeutic approach to MDS. In this review we summarize current recommendations and controversies surrounding HSCT for MDS, as well as the use of novel therapeutics in the pen-transplant period. Semin Oncol 38:693-704 (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：693 / 704
页数：12
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