Natural products to drugs: natural product-derived compounds in clinical trials

被引:626
作者
Butler, Mark S. [1 ,2 ]
机构
[1] MerLion Pharmaceut, Singapore 117528, Singapore
[2] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
关键词
D O I
10.1039/b514294f
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural product-derived compounds for which clinical trials have been halted or discontinued since 2005. Also discussed are natural product-derived drugs launched since 2005, new natural product templates and late-stage development candidates.
引用
收藏
页码:475 / 516
页数:42
相关论文
共 632 条
  • [1] Abou-Gharbia M, 2002, BIODIVERSITY: BIOMOLECULAR ASPECTS OF BIODIVERSITY AND INNOVATIVE UTILIZATION, P63
  • [2] *ADV LIF SCI, 2006, FORM 10 Q
  • [3] Advani R, 2003, CLIN CANCER RES, V9, P5187
  • [4] Aggarwal BB, 2007, ADV EXP MED BIOL, V595, P1
  • [5] Appetite suppression and weight reduction by a centrally active aminosterol
    Ahima, RS
    Patel, HR
    Takahashi, N
    Qi, Y
    Hileman, SM
    Zasloff, MA
    [J]. DIABETES, 2002, 51 (07) : 2099 - 2104
  • [6] Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB-regulated gene products
    Ahn, Kwang Seok
    Sethi, Gautam
    Chao, Ta-Hsiang
    Neuteboom, Saskia T. C.
    Chaturvedi, Madan M.
    Palladino, Michael A.
    Younes, Anas
    Aggarwal, Bharat B.
    [J]. BLOOD, 2007, 110 (07) : 2286 - 2295
  • [7] TOTAL SYNTHESIS OF HALICHONDRIN-B AND NORHALICHONDRIN-B
    AICHER, TD
    BUSZEK, KR
    FANG, FG
    FORSYTH, CJ
    JUNG, SH
    KISHI, Y
    MATELICH, MC
    SCOLA, PM
    SPERO, DM
    YOON, SK
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (08) : 3162 - 3164
  • [8] Pharmacological properties of the ubiquitous natural product betulin
    Alakurtti, Sami
    Makela, Taru
    Koskimies, Salme
    Yli-Kauhaluoma, J.
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 29 (01) : 1 - 13
  • [9] Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications
    Alarcn de la Lastral, C.
    Villegas, I.
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 : 1156 - 1160
  • [10] Molecular mechanisms of antibacterial multidrug resistance
    Alekshun, Michael N.
    Levy, Stuart B.
    [J]. CELL, 2007, 128 (06) : 1037 - 1050