Evidence for a large-scale brain system supporting allostasis and interoception in humans

被引：343

作者：

Kleckner, Ian R. ^{[1
]}

Zhang, Jiahe ^{[1
]}

Touroutoglou, Alexandra ^{[2
,3
,4
,5
,6
]}

Chanes, Lorena ^{[1
,4
,5
,6
]}

Xia, Chenjie ^{[4
,6
,7
]}

Simmons, W. Kyle ^{[8
,9
]}

Quigley, Karen S. ^{[1
,10
]}

Dickerson, Bradford C. ^{[4
,6
,7
]}

Barrett, Lisa Feldman ^{[1
,4
,5
,6
]}

机构：

[1] Northeastern Univ, Dept Psychol, 105-107 Forsyth St, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Dept Neurol, 15 Parkman St, Boston, MA 02114 USA

[3] Harvard Med Sch, 15 Parkman St, Boston, MA 02114 USA

[4] Athinoula Martinos Ctr Biomed Imaging, 149,13th St, Charlestown, MA 02129 USA

[5] Massachusetts Gen Hosp, Dept Psychiat, Psychiat Neuroimaging Div, 55 Fruit St, Boston, MA 02114 USA

[6] Harvard Med Sch, 55 Fruit St, Boston, MA 02114 USA

[7] Massachusetts Gen Hosp, Dept Neurol, Frontotemporal Disorders Unit, 55 Fruit St, Boston, MA 02114 USA

[8] Laureate Inst Brain Res, 6655 South Yale Ave, Tulsa, OK 74136 USA

[9] Univ Tulsa, Sch Community Med, 4502 East 41st St, Tulsa, OK 74135 USA

[10] Edith Nourse Rogers Mem VA Hosp, 200 Springs Rd, Bedford, MA 01730 USA

来源：

NATURE HUMAN BEHAVIOUR | 2017年 / 1卷 / 05期

关键词：

MEDIAL PREFRONTAL CORTEX; OLD-WORLD MONKEY; ANTERIOR CINGULATE CORTEX; FUNCTIONAL CONNECTIVITY; CORTICAL PROJECTIONS; INSULAR CORTEX; RHESUS-MONKEY; DEFAULT MODE; EFFERENT CONNECTIONS; AFFECTIVE EXPERIENCE;

D O I：

10.1038/s41562-017-0069

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Large-scale intrinsic brain systems have been identified for exteroceptive senses (such as sight, hearing and touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (N = 280 and N = 270) to evaluate the existence of an intrinsic allostatic-interoceptive system in the human brain. Another sample (N = 41) allowed us to evaluate the convergent validity of the hypothesized allostatic-interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain's functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.

引用

页数：14

共 228 条

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