factor VIII inhibitor;
non-haemophiliacs;
steroid resistant;
double-filtration plasmapheresis;
treatment;
D O I:
10.1046/j.1365-2141.1999.01220.x
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs, In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few patients show resistance to immunosuppressive therapy. We describe a non-haemophilic elderly patient with acquired FVIII inhibitor who failed to respond to prednisolone. He was treated with double-filtration plasmapheresis (DFPP) which resulted in a very rapid reduction in inhibitor levels and resolution of symptoms.