Successful treatment of a non-haemophilic patient with inhibitor to factor VIII by double-filtration plasmapheresis

被引:18
作者
Sunagawa, T
Uezu, Y
Kadena, K
Tokuyama, K
Kinjo, F
Saito, A
机构
[1] Univ Ryukyus, Fac Med, Dept Internal Med 1, Okinawa 9030215, Japan
[2] Urasoe Gen Hosp, Okinawa, Japan
关键词
factor VIII inhibitor; non-haemophiliacs; steroid resistant; double-filtration plasmapheresis; treatment;
D O I
10.1046/j.1365-2141.1999.01220.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Factor VIII (FVIII) inhibitors appear in 3-20% of haemophilia A patients after injection of FVIII concentrates. However, autoantibodies to FVIII are also reported in non-haemophiliacs, In these patients FVIII inhibitor disappears spontaneously or diminishes in response to immunosuppressive therapy. However, a few patients show resistance to immunosuppressive therapy. We describe a non-haemophilic elderly patient with acquired FVIII inhibitor who failed to respond to prednisolone. He was treated with double-filtration plasmapheresis (DFPP) which resulted in a very rapid reduction in inhibitor levels and resolution of symptoms.
引用
收藏
页码:465 / 467
页数:3
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