Steroid-Responsive Encephalitis in Coronavirus Disease 2019

被引：213

作者：

Pilotto, Andrea ^{[1
,2
]}

Odolini, Silvia ^{[3
,4
]}

Masciocchi, Stefano ^{[1
]}

Comelli, Agnese ^{[3
,4
]}

Volonghi, Irene ^{[1
]}

Gazzina, Stefano ^{[5
]}

Nocivelli, Sara ^{[1
]}

Pezzini, Alessandro ^{[1
]}

Foca, Emanuele ^{[3
,4
]}

Caruso, Arnaldo ^{[4
,6
]}

Leonardi, Matilde ^{[7
]}

Pasolini, Maria P. ^{[5
]}

Gasparotti, Roberto ^{[4
,8
]}

Castelli, Francesco ^{[3
,4
]}

Ashton, Nicholas J. ^{[9
,10
,11
,12
,13
]}

Blennow, Kaj ^{[9
,14
]}

Zetterberg, Henrik ^{[9
,14
,15
,16
]}

Padovani, Alessandro ^{[1
]}

机构：

[1] Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Pzzale Spedali Civili 1, I-25123 Brescia, Italy

[2] FERB ONLUS S Isidoro Hosp, Parkinsons Dis Rehabil Ctr, Trescore Balneario, BG, Italy

[3] Univ Brescia, Univ Div Infect & Trop Dis, Brescia, Italy

[4] ASST Spedali Civili Hosp, Brescia, Italy

[5] ASST Spedali Civili Brescia, Neurophysiol Unit, Brescia, Italy

[6] Univ Brescia, Dept Mol & Translat Med, Microbiol Unit, Brescia, Italy

[7] IRCCS Neurol Inst Besta, Neurol Publ Hlth Disabil Unit, Milan, Italy

[8] Univ Brescia, Dept Mol & Translat Med, Neuroradiol Unit, Brescia, Italy

[9] Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Molndal, Sweden

[10] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden

[11] Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Inst Clin Neurosci Inst, London, England

[12] South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England

[13] South London & Maudsley NHS Fdn, Biomed Res Unit Dementia, London, England

[14] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[15] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[16] UCL, UK Dementia Res Inst, London, England

来源：

ANNALS OF NEUROLOGY | 2020年 / 88卷 / 02期

基金：

英国医学研究理事会;

关键词：

CONSENSUS; COVID-19;

D O I：

10.1002/ana.25783

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Cerebrospinal fluid analyses during the acute stage were negative for SARS-CoV-2, positive for pleocytosis and hyperproteinorrachia, and showed increased interleukin-8 and tumor necrosis factor-alpha concentrations. Other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to COVID-19. ANN NEUROL 2020

引用

页码：423 / 427

页数：5

共 20 条

[1] COVID-19, a pandemic or not? [J].

不详 .

LANCET INFECTIOUS DISEASES, 2020, 20 (04) :383-383

[2] Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms [J].

Baig, Abdul Mannan ;

Khaleeq, Areeba ;

Ali, Usman ;

Syeda, Hira .

ACS CHEMICAL NEUROSCIENCE, 2020, 11 (07) :995-998

[3]

BERNARDVALNET R, 2020, EUR J NEUROL 0530

[4] Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity [J].

Dale, RC ;

Church, AJ ;

Surtees, RAH ;

Lees, AJ ;

Adcock, JE ;

Harding, B ;

Neville, BGR ;

Giovannoni, G .

BRAIN, 2004, 127 :21-33

[5] Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? [J].

Desforges, Marc ;

Le Coupanec, Alain ;

Dubeau, Philippe ;

Bourgouin, Andreanne ;

Lajoie, Louise ;

Dube, Mathieu ;

Talbot, Pierre J. .

VIRUSES-BASEL, 2020, 12 (01)

[6] Two Cases of Late-Onset Anti-NMDAr Auto-Immune Encephalitis After Herpes Simplex Virus 1 Encephalitis [J].

Dorcet, Guillaume ;

Benaiteau, Marie ;

Bost, Chloe ;

Mengelle, Catherine ;

Bonneville, Fabrice ;

Martin-Blondel, Guillaume ;

Pariente, Jeremie .

FRONTIERS IN NEUROLOGY, 2020, 11

[7] Clinical Characteristics of Coronavirus Disease 2019 in China [J].

Guan, W. ;

Ni, Z. ;

Hu, Yu ;

Liang, W. ;

Ou, C. ;

He, J. ;

Liu, L. ;

Shan, H. ;

Lei, C. ;

Hui, D. S. C. ;

Du, B. ;

Li, L. ;

Zeng, G. ;

Yuen, K. -Y. ;

Chen, R. ;

Tang, C. ;

Wang, T. ;

Chen, P. ;

Xiang, J. ;

Li, S. ;

Wang, Jin-lin ;

Liang, Z. ;

Peng, Y. ;

Wei, L. ;

Liu, Y. ;

Hu, Ya-hua ;

Peng, P. ;

Wang, Jian-ming ;

Liu, J. ;

Chen, Z. ;

Li, G. ;

Zheng, Z. ;

Qiu, S. ;

Luo, J. ;

Ye, C. ;

Zhu, S. ;

Zhong, N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) :1708-1720

[8] Can China's COVID-19 strategy work elsewhere? [J].

Kupferschmidt, Kai ;

Cohen, Jon .

SCIENCE, 2020, 367 (6482) :1061-1062

[9] The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients [J].

Li, Yan-Chao ;

Bai, Wan-Zhu ;

Hashikawa, Tsutomu .

JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (06) :552-555

[10] Neuronal Surface Antibody-Mediated Autoimmune Encephalitis [J].

Linnoila, Jenny J. ;

Rosenfeld, Myrna R. ;

Dalmau, Josep .

SEMINARS IN NEUROLOGY, 2014, 34 (04) :458-466

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