Positive contrast with therapeutic iron nanoparticles at 4.7 T

被引:1
作者
Sigovan, Monica [1 ]
Hamoudeh, Misara [2 ]
Al Faraj, Achraf [1 ]
Charpigny, Delphine [1 ]
Fessi, Hatem [2 ]
Canet-Soulas, Emmanuelle [1 ]
机构
[1] Univ Lyon 1, INSERM, CNRS, CREATIS LRMN,UMR 5220,U630, F-69365 Lyon, France
[2] Univ Lyon 1, Fac Pharm Lyon1, CPE Lyon,Lab Automat & Genie Procedes,UMR 5007, Pharmaceut & Pharmaceut Technol Dept,LAGEP,CNRS, F-69365 Lyon, France
关键词
Superparamagnetic iron oxide; Positive contrast; GRASP; MAGNETIC-FIELD; MRI; CELLS; PARTICLES;
D O I
10.1007/s10334-011-0258-7
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The purpose of the study was to show the feasibility of a positive contrast technique GRadient echo Acquisition for Superparamagnetic particles with Positive contrast (GRASP), for a specific type of magnetic particles, designed for tumor treatment under MRI monitoring. A simulation study was performed to estimate field inhomogeneity intensities induced by increasing concentrations of particles at different static fields. The GRASP sequence was setup on a 4.7 T Bruker system during an in vitro study. Six mice, included in the in vivo study received particles in the left calf muscle and contrast enhancement values, were measured over three time points, for both negative and positive contrast images. Comparing values obtained by simulation at 1.5, 3, and 4.7 T, the strongest susceptibility effect was obtained at 4.7 T. Based on simulation and in vitro data, gradient settings were chosen for in vivo imaging. GRASP resulted in bright regions at and around the injection site, and higher enhancement values, compared to standard GRE imaging. Both contrasts were useful for longitudinal follow-up, with a faster decay over time for GRASP. The magnetic nanoparticles for drug delivery can be detected using positive contrast. Combining imaging sequences, i.e., negative contrast and susceptibility methods, increased imaging specificity of large magnetic particles and enabled their follow-up for theranostic applications.
引用
收藏
页码:259 / 265
页数:7
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