Copper-Catalyzed Reduction of Azides with Hydrosilanes

被引：9

作者：

Chen, Yang ^{[1
]}

Yang, Lixin ^{[1
]}

Zhang, Xiao ^{[1
]}

Deng, Shengqi ^{[1
]}

You, Li ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610052, Sichuan, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 01期

关键词：

azides; carbene ligands; copper-catalyzed; reduction; silanes; RADICAL REDUCTION; AROMATIC AZIDES; AMINES; HYDRIDE; HYDROSILYLATION; PHOSPHINE; MILD; NHC;

D O I：

10.1002/slct.201702802

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The copper-catalyzed reduction of azides by reaction with hydrosilanes is reported. The most efficient CuCl/IPrHCl (IPr=N,N-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene) catalytic system by employing (EtO)(3)SiH as the reducing agent has been developed. Diverse amines and primary amides are obtained in moderate to excellent yields with high functional group tolerance under very mild conditions.

引用

页码：96 / 99

页数：4

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