Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

被引：40
作者：
Rombola, Laura [1 ]
Scuteri, Damiana [1 ]
Watanabe, Chizuko [2 ]
Sakurada, Shinobu [2 ]
Hamamura, Kengo [3 ]
Sakurada, Tsukasa [3 ]
Tonin, Paolo [4 ]
Corasaniti, Maria Tiziana [5 ]
Bagetta, Giacinto [1 ]
Morrone, Luigi Antonio [1 ]
机构：
[1] Univ Calabria, Dept Pharm Hlth Sci & Nutr, Preclin & Translat Pharmacol, I-87036 Arcavacata Di Rende, Italy
[2] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan
[3] Daiichi Coll Pharmaceut Sci, Dept Pharmacol Fukuoka 1, Fukuoka 8158511, Japan
[4] S Anna Inst, Reg Ctr Serious Brain Injuries, I-88900 Crotone, Italy
[5] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 07期
关键词：
aromatherapy; bergamot essential oil; serotonin neurotransmission; anxiety and motor behavioral tests; MONOSODIUM GLUTAMATE; OPEN-FIELD; PLUS-MAZE; ANXIETY; RAT; SEROTONIN; BEHAVIOR; ANTAGONIST; DEPRESSION; MICE;
D O I：
10.3390/ijms21072597
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((+/-)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.
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页数：14
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