The C-reactive protein to albumin ratio is a prognostic factor for stage I non-small cell lung cancer in elderly patients: JACS1303

被引：8

作者：

Miyazaki, Takuro ^{[1
]}

Saji, Hisashi ^{[2
]}

Nakamura, Hiroshige ^{[3
]}

Nagayasu, Takeshi ^{[1
]}

Okumura, Norihito ^{[4
]}

Tsuchida, Masanori ^{[5
]}

Sonobe, Makoto ^{[6
]}

Aokage, Keiju ^{[7
]}

Nakao, Masayuki ^{[8
]}

Haruki, Tomohiro ^{[3
]}

Okada, Morihito ^{[9
,12
]}

Suzuki, Kenji ^{[10
,12
]}

Chida, Masayuki ^{[11
]}

Yoshino, Ichiro ^{[13
,14
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg Oncol, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

[2] St Marianna Univ, Sch Med, Dept Chest Surg, Kawasaki, Kanagawa, Japan

[3] Tottori Univ, Fac Med, Dept Surg, Div Gen Thorac Surg, Tottori, Japan

[4] Kurashiki Cent Hosp, Dept Thorac Surg, Okayama, Japan

[5] Niigata Univ, Grad Sch Med & Dent Sci, Div Thorac & Cardiovasc Surg, Niigata, Japan

[6] Kyoto Univ, Grad Sch Med, Dept Thorac Surg, Kyoto, Japan

[7] Natl Canc Ctr Hosp East, Dept Thorac Oncol, Div Thorac Surg, Chiba, Japan

[8] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Thorac Surg Oncol, Tokyo, Japan

[9] Hiroshima Univ, Dept Surg Oncol, Hiroshima, Japan

[10] Juntendo Univ, Sch Med, Dept Gen Thorac Surg, Tokyo, Japan

[11] Dokkyo Med Univ, Dept Gen Thorac Surg, Shimotsuga, Japan

[12] Japanese Assoc Chest Surg, Comm Sci Affairs, Kyoto, Japan

[13] Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chiba, Japan

[14] Japanese Assoc Chest Surg, Kyoto, Japan

来源：

SURGERY TODAY | 2022年 / 52卷 / 10期

关键词：

Lung cancer; Surgery; Octogenarian; C-reactive protein; Albumin; PROTEIN/ALBUMIN RATIO; PULMONARY RESECTION; SCORE; OUTCOMES; RISK; COMPLICATIONS; PROPOSAL; IMPACT; COHORT;

D O I：

10.1007/s00595-022-02485-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose To establish the prognostic significance of C-reactive protein (CRP) and albumin in octogenarians with non-small cell lung cancer (NSCLC) based on the study of the Japanese Association for Chest Surgery (JACS 1303). Methods A total of 618 octogenarians with pathological stage I NSCLC, who underwent pulmonary resection, were included in the analysis. We conducted multivariable Cox regression analysis to evaluate the CRP to albumin ratio (CAR) as a potential prognostic factor. Other clinicopathological factors were also evaluated. Results The median age was 82 years. Operations included lobectomy (n = 388; 62.8%) segmentectomy (n = 95; 15%), and wedge resection (n = 135; 22%). Pathological stage IA was diagnosed in 380 (61.5%) patients. The 3-year (OS) and cancer-specific survival (CS) rates were 86.7% and 94.6%, respectively. OS was significantly higher for patients with low CAR (< 0.106) than for those with high CAR (>= 0.106) (hazard ratio = 3.13, 95% confidence interval: 1.99-4.93, p < 0.0001). Univariate analysis identified sex, poor performance status, smoking status, comorbidity, solid tumor, histology, high Glasgow prognostic scale, and high CAR as significant prognostic factors. Multivariate analysis identified only the CAR as a significant prognostic factor for both OS and CS. Conclusions Our analysis of the nationwide data demonstrated that the CAR is a useful prognostic factor for elderly patients with stage I NSCLC.

引用

页码：1463 / 1471

页数：9

共 30 条

[1] Impact of body composition, nutritional and inflammatory status on outcome of non-small cell lung cancer patients treated with immunotherapy [J].