Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine density

被引：20

作者：

Novaes, Leonardo Santana ^{[1
]}

dos Santos, Nilton Barreto ^{[1
]}

Perfetto, Juliano Genaro ^{[1
]}

Goosens, Ki Ann ^{[2
]}

Munhoz, Carolina Demarchi ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Av Prof Lineu Prestes 1524,Room 323, BR-05508000 Sao Paulo, SP, Brazil

[2] Massachusetts Gen Hosp, Dept Neurol, Chaelestown, MA 02129 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2018年 / 98卷

基金：

巴西圣保罗研究基金会;

关键词：

Stress; Anxiety; Environmental enrichment; Basolateral amygdala; Spine remodeling; SUFFICIENT; PATTERNS;

D O I：

10.1016/j.psyneuen.2018.07.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies showed that acute restraint stress or transient elevation of glucocorticoid (GC) stress hormones produces emergent changes in both anxiety behavior and dendritic branches in the basolateral amygdala complex (BLA) of rats. In this work, we demonstrate that exposure to environmental enrichment (EE) prevented stress-induced increases in anxiety (emerging 10 days post-stress) in adult rats without blocking stress-induced dendritic branch remodeling in the BLA nor stress-induced enhancement of GC serum levels.

引用

页码：6 / 10

页数：5

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