CSF lactate

被引：23

作者：

Baheerathan, Aravindhan ^{[1
]}

Pitceathly, Robert D. S. ^{[2
,3
]}

Curtis, Carmel ^{[3
,4
]}

Davies, Nicholas W. S. ^{[1
,5
]}

机构：

[1] Charing Cross Hosp, Dept Neurol, London W6 8RF, England

[2] UCL Queen Sq Inst Neurol, Dept Neuromuscular Dis, London, England

[3] Natl Hosp Neurol & Neurosurg, London, England

[4] Univ Coll London Hosp, Dept Microbiol, London, England

[5] Chelsea & Westminster Hosp, Dept Neurol, London, England

来源：

PRACTICAL NEUROLOGY | 2020年 / 20卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1136/practneurol-2019-002191

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lactate is produced from anaerobic glycolysis, which occurs in most tissues in the human body. Blood lactate is tested in most physiologically unwell patients in the Emergency Department and helps to guide treatment and prognosis. Cerebrospinal fluid (CSF) lactate, however, is not often measured. Various central nervous system (CNS) conditions lead to a rise in CSF lactate, including acute neurological infection, stroke, seizures and mitochondrial pathologies. This article discusses the utility and limitations of CSF lactate, highlighting specific clinical situations where it can help in the diagnosis of CNS infections and unexplained encephalopathy.

引用

页码：322 / 325

页数：4

共 13 条

[1] Capillary glucose meters cannot substitute serum glucose measurement to determine the cerebrospinal fluid to blood glucose ratio: A prospective observational study [J].

Asmolov, Romain ;

Rousseau, Geoffroy ;

Grammatico-Guillon, Leslie ;

Guillon, Antoine .

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2017, 34 (12) :854-856

[2] Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study [J].

Buch, Kristian ;

Bodilsen, Jacob ;

Knudsen, Andreas ;

Larsen, Lykke ;

Helweg-Larsen, Jannik ;

Storgaard, Merete ;

Brandt, Christian ;

Wiese, Lothar ;

Ostergaard, Christian ;

Nielsen, Henrik ;

Lebech, Anne-Mette .

INFECTIOUS DISEASES, 2018, 50 (07) :514-521

[3] The significance of elevated CSF lactate [J].

Chow, SL ;

Rooney, ZJ ;

Cleary, MA ;

Clayton, PT ;

Leonard, JV .

ARCHIVES OF DISEASE IN CHILDHOOD, 2005, 90 (11) :1188-1189

[4] Management of post-neurosurgical meningitis: narrative review [J].

Hussein, K. ;

Bitterman, R. ;

Shofty, B. ;

Paul, M. ;

Neuberger, A. .

CLINICAL MICROBIOLOGY AND INFECTION, 2017, 23 (09) :621-628

[5]

Huy NT, 2010, CRIT CARE, V14, DOI [10.1186/cc9395, 10.1186/cc9268]

[6] Predictive value of cerebrospinal fluid (CSF) lactate level versus CSF/blood glucose ratio for the diagnosis of bacterial meningitis following neurosurgery [J].

Leib, SL ;

Boscacci, R ;

Gratzl, O ;

Zimmerli, W .

CLINICAL INFECTIOUS DISEASES, 1999, 29 (01) :69-74

[7] Cerebrospinal Fluid Lactate as an Indicator for Post-Neurosurgical Bacterial Meningitis [J].

Lotfi, Rebai ;

Ines, Boussaidi ;

Aziz, Daghmouri M. ;

Mohamed, Badri .

INDIAN JOURNAL OF CRITICAL CARE MEDICINE, 2019, 23 (03) :127-130

[8] The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults [J].

McGill, F. ;

Heyderman, R. S. ;

Michael, B. D. ;

Defres, S. ;

Beeching, N. J. ;

Borrow, R. ;

Glennie, L. ;

Gaillemin, O. ;

Wyncoll, D. ;

Kaczmarski, E. ;

Nadel, S. ;

Thwaites, G. ;

Cohen, J. ;

Davies, N. W. S. ;

Miller, A. ;

Rhodes, A. ;

Read, R. C. ;

Solomon, T. .

JOURNAL OF INFECTION, 2016, 72 (04) :405-438

[9] INDEPENDENCE OF BLOOD AND CEREBROSPINAL FLUID LACTATE [J].

POSNER, JB ;

PLUM, F .

ARCHIVES OF NEUROLOGY, 1967, 16 (05) :492-&

[10]

Triepels RH, 1999, ANN NEUROL, V45, P787, DOI 10.1002/1531-8249(199906)45:6<787::AID-ANA13>3.0.CO

← 1 2 →