Immune cell interactions in tuberculosis

被引：76

作者：

Flynn, JoAnne L. ^{[1
,2
]}

Chan, John ^{[3
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Sch Med, Ctr Vaccine Res, Pittsburgh, PA 15260 USA

[3] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Dept Med,Ctr Emerging Pathogens, Newark, NJ 07103 USA

来源：

CELL | 2022年 / 185卷 / 25期

基金：

英国惠康基金;

关键词：

CD8(+) T-CELLS; NECROSIS-FACTOR-ALPHA; MYCOBACTERIUM-TUBERCULOSIS; B-CELLS; PHENOTYPIC HETEROGENEITY; ANTIGEN PRESENTATION; IL-1-BETA PRODUCTION; GRANULOMA-FORMATION; TUBERCLE-BACILLI; INTERFERON-GAMMA;

D O I：

10.1016/j.cell.2022.10.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite having been identified as the organism that causes tuberculosis in 1882, Mycobacterium tubercu-losis has managed to still evade our understanding of the protective immune response against it, defying the development of an effective vaccine. Technology and novel experimental models have revealed much new knowledge, particularly with respect to the heterogeneity of the bacillus and the host response. This re-view focuses on certain immunological elements that have recently yielded exciting data and highlights the importance of taking a holistic approach to understanding the interaction of M. tuberculosis with the many host cells that contribute to the development of protective immunity.

引用

页码：4682 / 4702

页数：21

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