The present study tested hypotheses concerning interpersonal problems and the course of brief psychodynamic treatment of generalized anxiety disorder (GAD). The authors found that the largest changes from pre- to post-therapy were evident for the Nonassertive, Exploitable, and Intrusive subscales of the Inventory of Interpersonal Problems. Relatively small changes were seen on the Overly Nurturant subscale, which was hypothesized to be most relevant to GAD. Changes in interpersonal problems were significantly associated with improvement in symptoms and worry. Brief dynamic therapy was not found to uniquely improve interpersonal problems compared with supportive therapy, although the psychodynamic approach was statistically and clinically superior to supportive therapy on symptomatic remission rates.