In order to effectively solve the high-rise building fire, the thesis analyzes 21 cases of high-rise building fires to provide data support for high-rise building fire safety decision-making. The results showed that, (1) indifference to fire safety is a principal factor, accounting for 57.14%. This was followed by electrical wires, accounting for 19%. (2) in the 21 cases of high-rise building fires, except three cases of construction, the remaining 18 cases caused 571 deaths, an average of 31.72 persons per case, reaching a "special serious fire" level. (3) 12 cases happened during the day, causing a total of 158 persons killed, an average of 13.17 deaths per case; 9 cases at night, a total of 414 deaths on average of 46 per case, about 3.49 times during the day, indicating that the harm of high-rise buildings fire is much greater than that during the day. The conclusionsare: (1) by strengthening high-rise building fire safety concept to eliminate the human factors, high-rise building fire risk can be greatly reduced. (2) by enhancing management and maintenance of electrical wiring system to improve fire-prevention facilities and systems, this can further reduce the number of high-rise building fires. (3) and also proposing alerts to prevent arson and sabotage activities of hostile terrorist.