Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells

被引：37
作者：
Alio Del Barrio, Jorge L. [1 ,2 ]
De la Mata, Ana [3 ,4 ,5 ]
De Miguel, Maria P. [6 ]
Arnalich-Montiel, Francisco [7 ,8 ]
Nieto-Miguel, Teresa [3 ,4 ,5 ,9 ]
El Zarif, Mona [10 ]
Cadenas-Martin, Marta [6 ]
Lopez-Paniagua, Marina [3 ,4 ,5 ]
Galindo, Sara [3 ,4 ,5 ]
Calonge, Margarita [3 ,4 ,5 ]
Alio, Jorge L. [1 ,2 ]
机构：
[1] Vissum Miranza Grp, Cornea Cataract & Refract Surg Unit, Alicante 03016, Spain
[2] Univ Miguel Hernandez, Div Ophthalmol, Alicante 03550, Spain
[3] Univ Valladolid, IOBA Inst Appl Ophthalmobiol, Valladolid 47011, Spain
[4] Inst Salud Carlos III, CIBER Bioingn Biomat & Nanomed, Madrid 28029, Spain
[5] Castile & Leon Networking Ctr Regenerat Med & Cel, Valladolid 47011, Spain
[6] La Paz Univ Hosp, Cell Engn Lab, IdiPAZ, Hlth Res Inst, Madrid 28046, Spain
[7] Ramon y Cajal Univ Hosp, Ophthalmol Dept, IRYCIS, Madrid 28034, Spain
[8] Miranza IOA, Cornea Unit, Madrid 28003, Spain
[9] Univ Valladolid, Dept Cell Biol Histol & Pharmacol, Valladolid 47002, Spain
[10] Opt Gen, Saida 1600, Lebanon
来源：
CELLS | 2022年 / 11卷 / 16期
关键词：
stem cells; adipose-derived stem cells; regenerative medicine; corneal transplant; corneal regeneration; decellularized cornea; cornea; corneal stroma; corneal epithelium; cellular therapy; mesenchymal stem cells; extracellular vesicles; OCULAR SURFACE; STROMAL CELLS; DRY EYE; BONE-MARROW; THERAPY; TISSUE; TRANSPLANTATION; GENERATION; TRANSPARENCY; RESTORATION;
D O I：
10.3390/cells11162549
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important advantage of being easily obtained (in an autologous manner) from low invasive procedures, rendering a high number of multipotent stem cells with the potential to differentiate into several cellular lineages, to show immunomodulatory properties, and to promote tissue regeneration by a paracrine action through the secretion of extracellular vesicles containing trophic factors. This secretome is currently being investigated as a potential source for a cell-free based regenerative therapy for human tissues, which would significantly reduce the involved costs, risks and law regulations, allowing for a broader application in real clinical practice. In the current article, we will review the existing preclinical and human clinical evidence regarding the use of such adipose-derived mesenchymal stem cells for the regeneration of the three main layers of the human cornea: the epithelium (derived from the surface ectoderm), the stroma (derived from the neural crest mesenchyme), and the endothelium (derived from the neural crest cells).
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页数：21
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