Impact of antibiotics on the human microbiome and consequences for host health

被引：384
作者：
Patangia, Dhrati, V [1 ,2 ,3 ]
Ryan, Cornelius Anthony [1 ]
Dempsey, Eugene [1 ]
Ross, Reynolds Paul [1 ,3 ]
Stanton, Catherine [2 ,3 ]
机构：
[1] Univ Coll Cork, Sch Microbiol, Cork, Ireland
[2] Teagasc Food Res Ctr, Moorepk, Cork P61 C996, Fermoy Co, Ireland
[3] APC Microbiome, Cork, Ireland
来源：
MICROBIOLOGYOPEN | 2022年 / 11卷 / 01期
基金：
爱尔兰科学基金会;
关键词：
antibiotic resistance; gut bacteria; microbiome; HUMAN GUT MICROBIOME; CLOSTRIDIUM-DIFFICILE INFECTION; NONOBESE DIABETIC MICE; LONG-TERM PERSISTENCE; INTENSIVE-CARE-UNIT; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; RESISTANCE GENES; SUBINHIBITORY CONCENTRATIONS; ESCHERICHIA-COLI;
D O I：
10.1002/mbo3.1260
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
It is well established that the gut microbiota plays an important role in host health and is perturbed by several factors including antibiotics. Antibiotic-induced changes in microbial composition can have a negative impact on host health including reduced microbial diversity, changes in functional attributes of the microbiota, formation, and selection of antibiotic-resistant strains making hosts more susceptible to infection with pathogens such as Clostridioides difficile. Antibiotic resistance is a global crisis and the increased use of antibiotics over time warrants investigation into its effects on microbiota and health. In this review, we discuss the adverse effects of antibiotics on the gut microbiota and thus host health, and suggest alternative approaches to antibiotic use.
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页数：23
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