Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population

被引:37
作者
Lu, Yonghai [1 ,2 ]
Wang, Yeli [1 ]
Liang, Xu [3 ]
Zou, Li [1 ]
Ong, Choon Nam [1 ,3 ]
Yuan, Jian-Min [4 ,5 ]
Koh, Woon-Puay [1 ,6 ]
Pan, An [7 ,8 ,9 ]
机构
[1] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore
[2] Qingdao Univ, Inst Nutr & Hlth, Qingdao 266071, Peoples R China
[3] Natl Univ Singapore, NUS Environm Res Inst, Singapore 117411, Singapore
[4] Univ Pittsburgh, Div Canc Control & Populat Sci, Canc Inst, Pittsburgh, PA 15232 USA
[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15232 USA
[6] Duke NUS Med Sch Singapore, Hlth Serv & Syst Res, Singapore 169857, Singapore
[7] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Epidemiol & Biostat, Wuhan 430030, Hubei, Peoples R China
[8] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China
[9] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan 430030, Hubei, Peoples R China
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
Essential amino acids; non-essential amino acids; type; 2; diabetes; serum; LC-MS/MS; BRANCHED-CHAIN; INSULIN-RESISTANCE; METABOLIC SIGNATURE; RISK; PROFILES; BIOMARKERS; PREDICTORS; LEUCINE; LIPIDS;
D O I
10.3390/metabo9010014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population.
引用
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页数:10
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