A new role of the rDNA and nucleolus in the nucleus-rDNA instability maintains genome integrity

被引：138

作者：

Kobayashi, Takehiko ^{[1
,2
]}

机构：

[1] Natl Inst Genet, Mishima, Shizuoka 4118540, Japan

[2] Grad Univ Adv Studies, SOKENDAI, Mishima, Shizuoka 4118540, Japan

来源：

BIOESSAYS | 2008年 / 30卷 / 03期

关键词：

D O I：

10.1002/bies.20723

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleolus is a region of the nucleus with high protein density and it acts as a ribosome factory. The nucleolus contains a distinct region of the genome, the ribosomal RNA gene repeats (rDNA) that supply ribosomal RNA (rRNA) molecules. The rDNA is the most-abundant gene and occupies a large part of the genome, for example, there are thousands of rDNA copies in the genomes of plant cells. Therefore, it is natural to suppose that the condition of the rDNA, such as its stability, might affect cellular functions. Here I would like to propose a new model regarding the roles of the rDNA and nucleolus. The key point of this model is that they act to preserve genome stability and trigger aging.

引用

页码：267 / 272

页数：6

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