Palladium-Catalyzed Oxidative Annulation of Pyrrolylalkyl-1H-azoles: Towards the Synthesis of Polyheterocyclic Arenes

被引：3

作者：

Tripathi, Krishna N. ^{[1
]}

Bansode, Avinash H. ^{[2
]}

Singh, Ravi P. ^{[1
]}

机构：

[1] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India

[2] Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 05期

关键词：

C-H functionalization; pyrroles; oxidative coupling; palladium; imidazoles; INTRAMOLECULAR CYCLIZATION; PYRROLO-PYRAZINES; DIRECT ARYLATIONS; DERIVATIVES; DESIGN; ACCESS; ROUTES;

D O I：

10.1055/s-0039-1691492

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient and regioselective palladium-catalyzed annulation protocol for a series of linear and terminally substituted 1,2- and 1,3-di(heteroaryl)alkanes to the corresponding polyheterocyclic arenes is reported. Herein, intramolecular oxidative coupling involving double C(sp(2))-H bond functionalization provides a feasible access to biheteroaryl systems annulated to a six-membered ring. The methodology is not restricted to six-membered annulations and was extended to the synthesis of compounds with a seven-membered ring and biheteroaryl core.

引用

页码：719 / 726

页数：8

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