Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres

被引:1
作者
Milto, I., V [1 ,2 ]
Ivanova, V. V. [1 ]
Shevtsova, N. M. [1 ]
Sukhodolo, I., V [1 ]
机构
[1] Siberian State Med Univ, Minist Hlth Russian Federat, Dept Morphol & Pathol, Tomsk, Russia
[2] Fed Med Biol Agcy Russia, Seversk Biophys Res Ctr, Dept Mol & Cellular Radiobiol, Seversk, Russia
关键词
magnetite nanoparticles; magnetite nanospheres; chitosan; leukocytes; IRON-OXIDE NANOPARTICLES;
D O I
10.1007/s10517-020-04802-z
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.
引用
收藏
页码:785 / 788
页数:4
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