Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual-Targeted Photothermal Therapy

被引：659
|
作者：
Cheng, Liang [1 ]
Yang, Kai [1 ]
Li, Yonggang [2 ]
Chen, Jianhua [2 ]
Wang, Chao [1 ]
Shao, Mingwang [1 ]
Lee, Shuit-Tong [3 ,4 ]
Liu, Zhuang [1 ]
机构：
[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou 215006, Jiangsu, Peoples R China
[3] City Univ Hong Kong, Ctr Super Diamond & Adv Films, Hong Kong, Hong Kong, Peoples R China
[4] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 32期
基金：
中国国家自然科学基金;
关键词：
imaging agents; multifunctional systems; nanoparticles; photothermal therapy; upconversion; IN-VIVO; FLUORESCENT NANOPARTICLES; BIOMEDICAL APPLICATIONS; GOLD NANOPARTICLES; CONTRAST AGENT; DRUG-DELIVERY; NANOCRYSTALS; NANOPHOSPHORS; LUMINESCENCE; NANOSHELLS;
D O I：
10.1002/anie.201101447
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Jack of all trades: A multifunctional nanoparticle (MFNP) integrates an upconversion nanoparticle (see picture, green), a layer of iron oxide nanoparticles (black), and a gold shell (red). The system can be used for in vitro targeted upconversion luminescence, magnetic resonance, and light scattering multimodal imaging of cells. The near-infrared optical absorption of MFNPs also enables photothermal destruction of cancer cells. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7385 / 7390
页数：6
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