Facile Preparation of Multifunctional Upconversion Nanoprobes for Multimodal Imaging and Dual-Targeted Photothermal Therapy

被引：658
作者：
Cheng, Liang [1 ]
Yang, Kai [1 ]
Li, Yonggang [2 ]
Chen, Jianhua [2 ]
Wang, Chao [1 ]
Shao, Mingwang [1 ]
Lee, Shuit-Tong [3 ,4 ]
Liu, Zhuang [1 ]
机构：
[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou 215006, Jiangsu, Peoples R China
[3] City Univ Hong Kong, Ctr Super Diamond & Adv Films, Hong Kong, Hong Kong, Peoples R China
[4] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 32期
基金：
中国国家自然科学基金;
关键词：
imaging agents; multifunctional systems; nanoparticles; photothermal therapy; upconversion; IN-VIVO; FLUORESCENT NANOPARTICLES; BIOMEDICAL APPLICATIONS; GOLD NANOPARTICLES; CONTRAST AGENT; DRUG-DELIVERY; NANOCRYSTALS; NANOPHOSPHORS; LUMINESCENCE; NANOSHELLS;
D O I：
10.1002/anie.201101447
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Jack of all trades: A multifunctional nanoparticle (MFNP) integrates an upconversion nanoparticle (see picture, green), a layer of iron oxide nanoparticles (black), and a gold shell (red). The system can be used for in vitro targeted upconversion luminescence, magnetic resonance, and light scattering multimodal imaging of cells. The near-infrared optical absorption of MFNPs also enables photothermal destruction of cancer cells. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7385 / 7390
页数：6
相关论文
共 38 条
[1]  
[Anonymous], 2006, ANGEW CHEM, DOI DOI 10.1002/ange.200602471
[2]  
[Anonymous], 2011, Angewandte Chemie
[3]   Small Upconverting Fluorescent Nanoparticles for Biomedical Applications [J].
Chatterjee, Dev K. ;
Gnanasammandhan, Muthu Kumara ;
Zhang, Yong .
SMALL, 2010, 6 (24) :2781-2795
[4]   Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery [J].
Chen, Yu ;
Chen, Hangrong ;
Zeng, Deping ;
Tian, Yunbo ;
Chen, Feng ;
Feng, Jingwei ;
Shi, Jianlin .
ACS NANO, 2010, 4 (10) :6001-6013
[5]   Multicolor In Vivo Imaging of Upconversion Nanopaticles with Emissions Tuned by Luminescence Resonance Energy Transfer [J].
Cheng, Liang ;
Yang, Kai ;
Shao, Mingwang ;
Lee, Shuit-Tong ;
Liu, Zhuang .
JOURNAL OF PHYSICAL CHEMISTRY C, 2011, 115 (06) :2686-2692
[6]   Highly-Sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles [J].
Cheng, Liang ;
Yang, Kai ;
Zhang, Shuai ;
Shao, Mingwang ;
Lee, Shuittong ;
Liu, Zhuang .
NANO RESEARCH, 2010, 3 (10) :722-732
[7]   Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer [J].
El-Sayed, IH ;
Huang, XH ;
El-Sayed, MA .
NANO LETTERS, 2005, 5 (05) :829-834
[8]   Gold nanostructures: engineering their plasmonic properties for biomedical applications [J].
Hu, Min ;
Chen, Jingyi ;
Li, Zhi-Yuan ;
Au, Leslie ;
Hartland, Gregory V. ;
Li, Xingde ;
Marquez, Manuel ;
Xia, Younan .
CHEMICAL SOCIETY REVIEWS, 2006, 35 (11) :1084-1094
[9]   Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy [J].
Hu, Shang-Hsiu ;
Gao, Xiaohu .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (21) :7234-+
[10]  
Jin YD, 2009, NAT NANOTECHNOL, V4, P571, DOI [10.1038/nnano.2009.193, 10.1038/NNANO.2009.193]
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