Ghrelin: A multifunctional hormone in non-mammalian vertebrates

被引：177

作者：

Kaiya, Hiroyuki ^{[1
]}

Miyazato, Mikiya ^{[1
]}

Kangawa, Kenji ^{[1
]}

Peter, Richard E. ^{[2
]}

Unniappan, Suraj ^{[3
]}

机构：

[1] Natl Cardiovasc Ctr, Res Inst, Dept Biochem, Suita, Osaka 5658565, Japan

[2] Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada

[3] York Univ, Dept Biol, Toronto, ON M3J 2R7, Canada

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 2008年 / 149卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amphibians; birds; brain; fish; food intake; ghrelin; gut; hormones; peptides; reptiles;

D O I：

10.1016/j.cbpa.2007.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, ghrelin is a non-amidated peptide hormone, existing in both acylated and non-acylated forms, produced mainly from the X/A or ghrelin cells present in the mucosal layer of the stomach. Ghrelin is a natural ligand of the growth hormone (GH) secretagogue-receptor (GHS-R), and functions primarily as a GH-releasing hormone and an orexigen, as well as having several other biological actions. Among non-mammalian vertebrates, amino acid sequence of ghrelin has been reported in two species of cartilaginous fish, seven species of teleosts, two species of amphibians, one species of reptile and six species of birds. The structure and functions of ghrelin are highly conserved among vertebrates. This review presents a concise overview of ghrelin biology in non-mammalian vertebrates. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：109 / 128

页数：20

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