NOD2/CARD15 gene influences disease behaviour but not IBD susceptibility in a Moroccan population

被引：5

作者：

Serbati, Nadia ^{[1
,3
]}

Badre, Wafaa ^{[2
]}

Diakite, Brehima ^{[1
,3
]}

Nadifi, Sellama ^{[1
,3
]}

机构：

[1] Med Sch Casablanca, Med Genet Lab, Casablanca, Morocco

[2] Univ Hospial Ibn Rochd, Dept Gastroenterol, Casablanca, Morocco

[3] Univ Ain Chock Hassanii, Ctr Doctoral Sci In Hlth Sci, Casablanca, Morocco

来源：

TURKISH JOURNAL OF GASTROENTEROLOGY | 2014年 / 25卷

关键词：

Inflammatory bowel disease; Crohn's disease; ulcerative colitis; NOD2/CARD15; gene; polymorphism; moroccan population; INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; NOD2; GENE; VARIANTS; CARD15; MUTATIONS; ASSOCIATION; POLYMORPHISMS; HETEROGENEITY; PREVALENCE;

D O I：

10.5152/tjg.2014.3870

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: IBD (Crohn's disease and Ulcerative Colitis) is chronic and multifactorial disease of the gastrointestinal tract. Till now, his pathogenesis remains unclear. It involves innate immunity, environmental component and genetic predisposition. Polymorphisms in NOD2/CARD15 have been implicated in Crohn's disease in several ethnic groups. The purpose of our study was to assess the frequency of the three major variants of this gene (Leu1007fsinsC, R702W, and G908R) in Moroccan IBD patients and to determine a possible effect of these variants on Disease's phenotype and clinical course. Materials and Methods: A total of 96 Moroccan unrelated IBD patients and 114 healthy controls were genotyped (PCR-RFLP method) for the three main polymorphisms. Results: In this study, no correlation was found between NOD2/CARD15 polymorphisms and ulcerative colitis or Crohn's disease in our population. Nevertheless, 3020insC (Leu1007fsinsC) variant was associated to a structuring behaviour on CD patients. Conclusion: These findings suggest that NOD2/CARD15 influences disease behaviour but not susceptibility to crohn's disease in Moroccan IBD patients.

引用

页码：122 / 128

页数：7

共 39 条

[1] The molecular classification of the clinical manifestations of Crohn's disease [J].

Ahmad, T ;

Armuzzi, A ;

Bunce, M ;

Mulcahy-Hawes, K ;

Marshall, SE ;

Orchard, TR ;

Crawshaw, J ;

Large, O ;

De Silva, A ;

Cook, JT ;

Barnardo, M ;

Cullen, S ;

Welsh, KI ;

Jewell, DP .

GASTROENTEROLOGY, 2002, 122 (04) :854-866

[2]

de Acosta MB, 2010, REV ESP ENFERM DIG, V102, P321, DOI 10.4321/s1130-01082010000500006

[3]

Cavalli-Sforza L.L., 1994, HIST GEOGRAPHY HUMAN

[4]

Derakhshan Faramarz, 2008, Indian J Gastroenterol, V27, P8

[5] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [J].

Duerr, Richard H. ;

Taylor, Kent D. ;

Brant, Steven R. ;

Rioux, John D. ;

Silverberg, Mark S. ;

Daly, Mark J. ;

Steinhart, A. Hillary ;

Abraham, Clara ;

Regueiro, Miguel ;

Griffiths, Anne ;

Dassopoulos, Themistocles ;

Bitton, Alain ;

Yang, Huiying ;

Targan, Stephan ;

Datta, Lisa Wu ;

Kistner, Emily O. ;

Schumm, L. Philip ;

Lee, Annette T. ;

Gregersen, Peter K. ;

Barmada, M. Michael ;

Rotter, Jerome I. ;

Nicolae, Dan L. ;

Cho, Judy H. .

SCIENCE, 2006, 314 (5804) :1461-1463

[6] Mutations in CARD15 and smoking confer susceptibility to Crohn's disease in the Danish population [J].

Ernst, Anja ;

Jacobsen, Bent ;

Ostergaard, Mette ;

Okkels, Henrik ;

Andersen, Vibeke ;

Dagiliene, Enrika ;

Pedersen, Inge S. ;

Thorsgaard, Niels ;

Drewes, Asbjorn M. ;

Krarup, Henrik B. .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2007, 42 (12) :1445-1451

[7] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease [J].

Fisher, Sheila A. ;

Tremelling, Mark ;

Anderson, Carl A. ;

Gwilliam, Rhian ;

Bumpstead, Suzannah ;

Prescott, Natalie J. ;

Nimmo, Elaine R. ;

Massey, Dunecan ;

Berzuini, Carlo ;

Johnson, Christopher ;

Barrett, Jeffrey C. ;

Cummings, Fraser R. ;

Drummond, Hazel ;

Lees, Charlie W. ;

Onnie, Clive M. ;

Hanson, Catherine E. ;

Blaszczyk, Katarzyna ;

Inouye, Mike ;

Ewels, Philip ;

Ravindrarajah, Radhi ;

Keniry, Andrew ;

Hunt, Sarah ;

Carter, Martyn ;

Watkins, Nick ;

Ouwehand, Willem ;

Lewis, Cathryn M. ;

Cardon, Lon ;

Lobo, Alan ;

Forbes, Alastair ;

Sanderson, Jeremy ;

Jewell, Derek P. ;

Mansfield, John C. ;

Deloukas, Panos ;

Mathew, Christopher G. ;

Parkes, Miles ;

Satsangi, Jack .

NATURE GENETICS, 2008, 40 (06) :710-712

[8] Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility [J].

Franke, Andre ;

Balschun, Tobias ;

Karlsen, Tom H. ;

Sventoraityte, Jurgita ;

Nikolaus, Susanna ;

Mayr, Gabriele ;

Domingues, Francisco S. ;

Albrecht, Mario ;

Nothnagel, Michael ;

Ellinghaus, David ;

Sina, Christian ;

Onnie, Clive M. ;

Weersma, Rinse K. ;

Stokkers, Pieter C. F. ;

Wijmenga, Cisca ;

Gazouli, Maria ;

Strachan, David ;

McArdle, Wendy L. ;

Vermeire, Severine ;

Rutgeerts, Paul ;

Rosenstiel, Philip ;

Krawczak, Michael ;

Vatn, Morten H. ;

Mathew, Christopher G. ;

Schreiber, Stefan .

NATURE GENETICS, 2008, 40 (11) :1319-1323

[9] Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population [J].

Gazouli, Maria ;

Mantzaris, Gerassimos ;

Kotsinas, Athanassios ;

Zacharatos, Panayotis ;

Papalambros, Efstathios ;

Archimandritis, Athanassios ;

Ikonomopoulos, John ;

Gorgoulis, Vassilis G. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2005, 11 (05) :681-685

[10] Non-association of Crohn's disease with NOD2 gene variants in Moroccan patients [J].

Hama, I. ;

Ratbi, I. ;

Reggoug, S. ;

Elkerch, F. ;

Kharrasse, G. ;

Errabih, I. ;

Ouazzani, H. ;

Sefiani, A. .

GENE, 2012, 499 (01) :121-123

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