Oral microbiota and Alzheimer's disease: Do all roads lead to Rome?

被引：96

作者：

Sureda, Antoni ^{[1
,2
]}

Daglia, Maria ^{[3
,4
]}

Castilla, Sandro Arguelles ^{[5
]}

Sanadgol, Nima ^{[6
,7
]}

Nabavi, Seyed Fazel ^{[8
]}

Khan, Haroon ^{[9
]}

Belwal, Tarun ^{[10
]}

Jeandet, Philippe ^{[11
]}

Marchese, Anna ^{[12
]}

Pistollato, Francesca ^{[13
]}

Forbes-Hernandez, Tamara ^{[14
]}

Battino, Maurizio ^{[14
,15
,16
]}

Berindan-Neagoe, Ioana ^{[17
,18
,19
]}

D'Onofrio, Grazia ^{[20
]}

Nabavi, Seyed Mohammad ^{[8
]}

机构：

[1] Univ Balearic Isl, CIBEROBN Physiopathol Obes & Nutr, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Balearic Island, Spain

[2] IdisBa, Palma De Mallorca, Balearic Island, Spain

[3] Univ Naples Federico II, Dept Pharm, Naples, Italy

[4] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Jiangsu, Peoples R China

[5] Univ Seville, Dept Physiol, Fac Pharm, Seville, Spain

[6] Univ Zabol, Dept Biol, Fac Sci, Zabol, Iran

[7] Univ Sao Paulo, Dept Chem & Phys, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP, Brazil

[8] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

[9] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan

[10] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Zhejiang Key Lab Agri Food Proc, Key Lab Agroprod Postharvest Handling,Minist Agr, Hangzhou, Peoples R China

[11] Univ Reims, Induced Resistance & Plant Bioprotect, Fac Sci, F-51687 Reims, France

[12] Univ Genoa, Microbiol Unit, DISC, Genoa, Italy

[13] Univ Europea Atlantico, Ctr Hlth & Nutr, Santander, Spain

[14] Univ Vigo, Nutr & Food Sci Grp, Dept Analyt & Food Chem, CITACA,CACTI, Vigo Campus, Vigo, Spain

[15] Univ Politecn Marche, Dept Clin Sci, Ancona, Italy

[16] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China

[17] Iuliu Hatieganu Univ Med & Pharm, MEDFUTURE Res Ctr Adv Med, 23 Marinescu St, Cluj Napoca, Romania

[18] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, 23 Marinescu St, Cluj Napoca 400337, Romania

[19] Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom & Expt Pathol, 34-36 Republicii St, Cluj Napoca, Romania

[20] Fdn Casa Sollievo Sofferenza, Unit Geriatr, Dept Med Sci, San Giovanni Rotondo, Italy

来源：

PHARMACOLOGICAL RESEARCH | 2020年 / 151卷

关键词：

Alzheimer's disease; Amyloid-beta; Oral microbiome; Periodontal disease; HERPES-SIMPLEX-VIRUS; LACTOPEROXIDASE-CONTAINING FOOD; MILD COGNITIVE IMPAIRMENT; STREPTOCOCCUS-MUTANS; DENTAL-CARIES; PORPHYROMONAS-GINGIVALIS; AMYLOID FORMATION; BIOFILM FORMATION; ANTIMICROBIAL ACTIVITY; SEVERE PERIODONTITIS;

D O I：

10.1016/j.phrs.2019.104582

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link between some infectious diseases caused by oral microbiota and AD. Oral microbiota dysbiosis is purported to contribute either directly to amyloid protein production, or indirectly to neuroinflammation, occurring as a consequence of bacterial invasion. Over the last decade, the development of Human Oral Microbiome database (HOMD) has deepened our understanding of oral microbes and their different roles during the human lifetime. Oral pathogens mostly cause caries, periodontal disease, and edentulism in aged population, and, in particular, alterations of the oral microbiota causing chronic periodontal disease have been associated with the risk of AD. Here we describe how different alterations of the oral microbiota may be linked to AD, highlighting the importance of a good oral hygiene for the prevention of oral microbiota dysbiosis.

引用

页数：15

共 234 条

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