The role of E-proteins in B- and T-lymphocyte development

被引：76

作者：

Bain, G ^{[1
]}

Murre, C ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

来源：

SEMINARS IN IMMUNOLOGY | 1998年 / 10卷 / 02期

关键词：

E proteins; lymphoid development; transcription factors;

D O I：

10.1006/smim.1998.0116

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Development of lymphocytes from hematopoietic stem cells is controlled, in part, by the activity of transcriptional regulatory proteins. In particular, one class of helix-loop-helix proteins, termed E-proteins, have been implicated in the regulation of gene expression during B-cell development. Recent analysis of gene-targeted mice has allowed a direct assessment of the functional roles of several E-protein family members in hematopoiesis. In this review we describe the defects in B- and T-lymphocyte development in mice carrying targeted mutations in the E-protein genes and discuss our current understanding of the rob of these proteins in lymphoid development.

引用

页码：143 / 153

页数：11

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