The social brain in schizophrenia

被引:0
作者
Loeffler, N. [1 ]
Berkefeld, A. [1 ]
Kaaden, S. [1 ]
Reiff, J. [1 ]
Braus, D. F. [1 ]
机构
[1] Dr Horst Schmidt Klin GmbH, Klin & Poliklin Psychiat & Psychotherapie, HSK, Wiesbaden, Germany
关键词
Visual scanpath; schizophrenia; endophenotype; social cognition; ANTIPSYCHOTIC-DRUGS; MAINTENANCE THERAPY; NEGATIVE SYMPTOMS; QTC INTERVAL; CLOZAPINE; METAANALYSIS; RISPERIDONE; HALOPERIDOL; PSYCHIATRY; PREVENTION;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Human beings are inherent social animals. Social cognition and interaction are essential tools in understanding other people and coming into contact with them. A major portion of the brain is responsible for the neuronal regulation of these processes. Areas of the frontal lobe, the fusiform gyrus and the amygdala with its connections play an important role in this neuronal network called the social brain. Schizophrenia is a disease where several subtypes have extensive deficits in social cognition and social skills. Overlaps between the social brain and the pathophysiology of schizophrenic diseases are in part responsible for these deficits. Looking at the specific subtypes, emphasis should be placed on the impaired visual exploration of faces with emotional valence and social situations. At present there is no adequate way to differentiate these subtypes depending on their psychopathology. This is, however, relevant and desirable for clinical use, to model an individualized therapy plan and make accurate decisions about specific rehabilitation based on objective parameters. Part of the following discussion will be, presenting an easy and reliable approach to identify those subtypes and creating perspectives for a more personalized therapy based on results from previous research.
引用
收藏
页码:226 / 237
页数:12
相关论文
共 46 条
[1]  
Allison DB, 1999, AM J PSYCHIAT, V156, P1686
[2]  
AMACA M, 2003, J CLIN PSYCHIAT, V64, P598
[3]  
[Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
[4]  
*APA, 2004, AM J PSYCHIAT, V161
[5]  
BAAS H, 2001, THERAPIE NEUROPSYCHI
[6]   Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine [J].
Carrillo, JA ;
Herráiz, AG ;
Ramos, SI ;
Gervasini, G ;
Vizcaíno, S ;
Benítez, J .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2003, 23 (02) :119-127
[7]   A comparison of risperidone and haloperidol for the prevention of relapse in patients with schizophrenia [J].
Csernansky, JG ;
Mahmoud, R ;
Brenner, R .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (01) :16-22
[8]  
DAVIS JM, 1975, AM J PSYCHIAT, V132, P1237
[9]  
DAVIS JM, 1985, J CLIN PSYCHIAT, V46, P18
[10]  
Degner D, 2010, PSYCHOPHARMAKOTHERAP, V17, P51