Are psychotic symptoms related to vagus nerve stimulation in epilepsy patients?

被引:0
作者
De Herdt, V
Boon, P
Vonck, K
Goossens, L
Nieuwenhuis, L
Paemeleire, K
Meire, V
Michielsen, G
Dewaele, F
Baert, E
van Roost, D
机构
[1] State Univ Ghent Hosp, Dept Neurol, Reference Ctr Refractory Epilepsy, B-9000 Ghent, Belgium
[2] State Univ Ghent Hosp, Dept Neurosurg, B-9000 Ghent, Belgium
关键词
refractory epilepsy; vagus nerve stimulation; psychosis; epilepsy surgery; forced normalisation;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Four patients with refractory epilepsy presented with psychotic symptoms following treatment with vagus nerve stimulation (VNS) to control seizures. Besides its anti-epileptic effect VNS has been shown to have an effect on various cognitive and behavioural functions. VNS is known to increase alertness and reduce sedation, which is independent from seizure control. VNS has also been shown to positively affect cognition and to exert strong antidepressant effects. Co-morbidity in epilepsy often comprises psychiatric illnesses. Increased psychiatric symptoms have mainly been described in association with successful outcome following epilepsy surgery as a result of forced normalisation'. Different hypotheses on the underlying aetiology of VNS-induced psychotic symptoms other than the previously described forced normalisation' are discussed.
引用
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页码:170 / 175
页数:6
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