Sequential Injection Analysis Hyphenated with Other Flow Techniques: A Review

In the last two decades, sequential injection analysis (SIA) became an important automation tool in several analytical fields as it provided advantages in terms of versatility, robustness, and consumption of samples and reagents. The noteworthy versatility of an SIA selection valve allowed its association with several units, including devices typically associated with other flow techniques, resulting in generally better analytical performance. This review discusses the hyphenization of SIA with other flow approaches outlining its advantages and motivations, which are related mainly with sample manipulation and solutions management. The future trends and perspectives in this field are also addressed.